Main Article Content
Background: Dyslipidemia is major risk factor of non-communicable disease and nutraceutical like red yeast rice (RYR) may be helpful as alternative to lowering lipid profile in dyslipidemia.
Research objectives: This literature is to critically analyze the comparison RYR and simvastatin in lowering lipid profile.
Methods: A search for relevant literatures in PubMed, Scopus, Cochrane, and Science Direct was conducted. We assessing the relevancy and eligibility of the literatures. Three literatures were selected and critically appraised.
Results: There were no significant different between RYR and statin group for triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), especially the total cholesterol (TC) and the low-density lipoprotein-cholesterol (LDL-C) level. Red yeast rice (RYR) show less fatigue side effect than statin.
Conclusions: Nutraceutical like RYR can be an alternative to lowering lipid profile especially TC level and LDL-C level and solution for patients who experience statin-associated myalgia.
Keywords: red yeast rice, monacolin K, simvastatin, lipid profile
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